The Toker Laboratory

2016

 

Welcome to the Toker lab home page

 

Alex Toker is a Professor in the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School, and Chief of the Division of Signal Transduction in Departments of Medicine, Pathology and Cancer Center. The lab has membership in the Biological and Biomedical Sciences PhD Program, the Dana-Farber/Harvard Cancer Center, and the Ludwig Center at Harvard.

Our research focuses on the cell and molecular biology of cancer. We are investigating the mechanisms by which signaling pathways impact tumor cell survival, invasion and metastasis. We are also studying metabolic alterations in tumor cells and how these lead to vulnerabilities that can be used to target tumors with specific therapies.  Our goal is to decipher the complex mechanisms by which these pathways impact cancer progression, with the ultimate goal of developing drugs that interfere with malignancy.

 
Recent Lab News
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  1. BulletThe lab bids farewell to Whitney Henry, who will be moving to MIT and the laboratory of Bob Weinberg for her post-doctoral fellowship. Best of luck Whitney, we will miss you!


  1. BulletThe lab bids farewell to Kristin Brown, who will be starting her own research laboratory at the Peter MacCallum Cancer Center in Melbourne, Australia! Best of luck Kristin, we will miss you!


  1. BulletThe lab bids farewell to Tiffany Tsang, who will be starting graduate school at U Penn! Best of luck Tiffany, we will miss you!


  1. BulletThe lab welcomes Hui Liu, Instructor in Medicine, and KangKang Yang, Research Assistant, as the newest members of the Toker lab! Welcome!!


  1. BulletThe lab welcomes Laura Ghisolfi, new Senior Research Associate. Welcome Laura!


  1. BulletBanner event! Whitney Henry was married to Joel Durand in a

     beautiful ceremony in St. Lucia, June 11!! Congrats to the lovely couple!


  1. BulletAlex was awarded a new R01 grant from the NCI on:

     Exploiting Metabolic Vulnerabilities in the PI3K and Akt

     Pathway in Cancer for Therapeutic Benefit


  1. BulletAlex gave a seminar at Albert Einstein College of Medicine in the

    Department of Developmental and Molecular Biology, May 24.


  1. BulletAlex gave a talk at the FASEB Science Research Conference

     Cell Signaling in Cancer: From Mechanisms to Therapy in Snowmass, CO.


  1. BulletWhitney Henry received her PhD From Harvard University during the 2106

    Commencement Exercises!!


  1. BulletPaper Published! Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nat Cell Biol. 2016 May;18(5):572-8. doi: 10.1038/ncb3341.

        See the BIDMC press release and other press here (Science Daily) and here (HMS).  


  1. BulletPaper Published! Maria Mancini, Evan Lien and Alex Toker. Oncogenic ATK1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis. Oncotarget 2016, DOI: 10.18632/oncotarget.8191

        The paper made the cover, and you can also see an interview with Alex and Maria here!


  1. BulletThe lab welcomes Sneha Dutta from the Harvard School of Public Health for her PhD rotation!


  1. BulletThe lab welcomes Caterina Vianello, from the University of Padova, joining the lab for 6 months. Welcome Caterina! 


  1. BulletReview published! Renee Geck and Alex Toker. Nonessential Amino Acid Metabolism in Cancer. Advances in Biological Regulation, 2016: Jan 21.pii: S2212-4926(15)30042-7. doi: 10.1016/j.jbior.2016.01.001.


  1. BulletEvan Lien has been awarded an Albert J. Ryan Fellowship for 2016. Congratulations Evan!


  1. Bullet Lab Baby!! Alex Toker and Nicole Homeier welcomed a beautiful baby girl,

     Leyla Lea Homeier-Toker.


  1. BulletAlex gave a seminar at Hokkaido University, Institute for Genetic Medicine,

    Sapporo, Japan, on January 29 2016.



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