The Toker Laboratory



Welcome to the Toker lab home page


Alex Toker is a Professor in the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School, and Chief of the Division of Signal Transduction in Departments of Medicine, Pathology and Cancer Center. The lab has membership in the Biological and Biomedical Sciences PhD Program and also the Dana-Farber/Harvard Cancer Center.

Our research focuses on the cell and molecular biology of cancer. We are investigating the mechanisms by which signaling pathways impact tumor cell survival, invasion and metastasis. The goal is to decipher the complex mechanisms by which these pathways impact cancer progression, with the ultimate goal of developing drugs that interfere with malignancy.

Recent Lab News
Email Me
  1. BulletThe lab bids farewell to Kali Ferrell, Toker lab manager who is moving back to Seattle to pursue new and exciting adventures. Best of luck Kali!!

  1. BulletPreview published! Toker A, Rameh L. PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K? Cancer Cell. 2015 Aug 10;28(2):143-5.

  1. BulletAlex gave a talk at the FASEB Science Research Conference on Protein Kinases and Protein Phosphorylation in Itasca, IL, July 19-24.

  1. BulletThe lab bids farewell to Emilie Clement, who is joining CPC Scientific.

      Best of luck Emilie!

  1. BulletThe lab welcomes Renee Geck who joins the Toker lab for her PhD!

  1. BulletToker lab Summer Fun Day at Kimball Farm!! Friday June 26.

      Mini golf, bumper boats, ice cream and more!

  1. BulletAlex was featured in an ASBMB Today father’s day piece about scientists dads!

  1. BulletPaper published! Kristin K. Brown, Laleh Montaser-Kouhsari, Andrew H. Beck, Alex Toker.

     MERIT40 is an Akt substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy.

     Cell Reports 11, 1-9, June 9 2015.

  1. BulletThe lab welcomes Rubye Peyser and Kelsey Gallant, undergraduate

     summer interns in the Toker lab.

  1. BulletWhitney Henry was awarded a Women in Cancer Research (WICR)

     Scholar Award at the AACR Annual Meeting in Philadelphia! Congrats Whitney!!

  1. BulletAlex Toker, Kristin Brown and Whitney Henry attended the Annual AACR

    Meeting in Philadelphia, April 18-22 2015. Alex chaired a mini-symposium,

    and Kristin and Whitney presented posters!

  1. BulletWhitney Henry has been busy! She presented posters at the New England Science Symposium (April 11, 2015), the 11th Annual Junior Investigators’ Health Disparities Research Poster Session at DF/HCC (May 7th 2015) and the Harvard Graduate Women in Science and Engineering Symposium (April 25, 2015).

  1. BulletAbbe Clark has been awarded an F31 pre-doctoral fellowship from the NIH!

     Congratulations Abbe!

  1. BulletPaper published! Kaunisto A, Henry WS, Montaser-Kouhsari L, Jaminet SC ,

     Oh EY, Zhao L, Luo HR, Beck AH, Toker A. NFAT1 promotes intratumoral

     neutrophil infiltration by regulating IL8 expression in breast cancer.

     Mol Oncol. 2015 Feb 19. pii: S1574-7891(15)00027-7.

     doi: 10.1016/j.molonc.2015.02.004.

  1. BulletEvan Lien has been awarded a Cell and Developmental Biology Training Program Award from HMS! Congrats Evan!!

  1. BulletReview published! Brown, K. and Toker, A. The Phosphoinositide 3-Kinase Pathway and Therapy Resistance in Cancer.  F1000Prime Rep2015, 7:13 (doi: 10.12703/P7-13)

  1. BulletAlex, Evan, Christian and Kristin attended the Keystone Symposia on ‘PI 3-Kinase Signaling Pathways in Disease’ in Vancouver, Canada, January 13-18. Alex gave a talk and Evan and Kristin had posters.


  1. BulletPaper published! Jessica A. Gasser, Hiroyuki Inuzuka, Alan W. Lau, Wenyi Wei,

     Rameen Beroukhim, Alex Toker, SGK3 Mediates INPP4B-Dependent PI3K

     Signaling in Breast Cancer, Molecular Cell 2014,

  1. BulletAlex gave a seminar at Tufts University School of Medicine in the Sackler School

     of Biomedical Sciences on October 28, 2014.

  1. BulletAlex gave a talk at the AACR focused meeting

     ‘Targeting the PI3K-mTOR Network in Cancer’, Philadelphia, PA, September 14-17, 2014.

  1. BulletThe lab welcomes Renee Geck for her first rotation in the HMS BBS program. Welcome Renee!!

  1. BulletThe lab welcomes Tiffany Tsang, new Research Assistant in the lab. Welcome Tiffany!!

  1. BulletCasey Stottrup has left the lab to attend graduate school. Best of luck Casey!

  1. BulletAlex presented a talk at the FASEB Science Research Conference on ‘Lipids and Lipid-Regulated Kinases in Cancer’ in Steamboat Springs, CO, July 27-August 1.

  1. BulletHannah Anthony has left the lab to attend graduate school. Best of luck Hannah!

  1. BulletAlex organized and gave a talk at Lewposium 2014!

     The Lewis Cantley Legacy: 20 years of Trailblazing Cancer

     Research at Beth Israel Deaconess Medical Center, June 27, 2014.

  1. BulletAlex gave a seminar at the UC Davis Cancer Center on May 15 2014

  1. BulletPaper published! Chin YM, Yuan X, Balk SP, Toker A. PTEN-deficient

     tumors depend on Akt2 for maintenance and survival.

     Cancer Discov. 2014 May 16 doi:10.1158/2159-8290.CD-13-0873

        and we made the cover!!

  1. BulletAlex gave a talk at the Biochemical Society Symposium on Membrane

     Morphology and Function in Fara San Martino, Abruzzo, Italy, May 5-8.

  1. BulletWhitney Henry was selected as a 2014 Harvard Horizons Scholar, and

     presented a talk at the Harvard Horizons Symposium at the Sanders Theatre,

     April 22nd, 2014. Congrats Whitney!! Video feed of her presentation here!

  1. BulletJessica Bradshaw has left the lab to pursue a post-doc at The Broad Institute

     of MIT and Harvard in the lab of David Altshuler. Best of luck Jess beta!

  1. BulletAlex has been appointed Chief of the Division of Signal Transduction

     in the Department of Medicine, Department of Pathology and Cancer Center

     at the BIDMC. He also leads the Program in Cancer Signaling at the Cancer Center.

  1. BulletAlex presented a talk at the 2014 AACR Annual Meeting, San Diego, April 4-9.

  1. BulletSivan Elloul has left the lab and joined Karyopharm. Bets of luck Sivan!

  1. BulletThe lab attended the 2014 Cold Spring Harbor Symposium on PTEN Pathways and Targets, March 25-28. Alex and Christian gave talks, and Emilie, Evan and Rebecca presented posters.

  1. BulletWhitney Henry has been awarded an Albert J. Ryan Fellowship for 2014. Congratulations Whitney!

  1. BulletAlex gave a talk at the Novartis Institutes for Biomedical Research in Basel, Switzerland on January 22, 2014.

  1. BulletAlex presented a talk at Cancer Grand Rounds at SUNY Stonybrook on January 9 2014.

Archived News