The Toker Laboratory



Welcome to the Toker lab home page


Alex Toker is a Professor in the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School. The lab has membership in the Biological and Biomedical Sciences PhD Program and also the Dana-Farber/Harvard Cancer Center. The lab is located on the 6th floor of the Center for Life Sciences building. 

Research in the laboratory focuses on the cell and molecular biology of cancer. We are investigating the mechanisms by which signaling pathways impact tumor cell survival, invasion and metastasis. The goal is to decipher the complex mechanisms by which these pathways impact cancer progression, with the ultimate goal of developing drugs to interfere with malignancy and metastasis.

Recent Lab News
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  1. BulletWhitney Henry was selected as a 2014 Harvard Horizons Scholar, and

     presented a talk at the Harvard Horizons Symposium at the Sanders Theatre,

     April 22nd, 2014. Congrats Whitney!! Photos and video feeds to follow soon!

  1. BulletJessica Bradshaw has left the lab to pursue a post-doc at The Broad Institute

     of MIT and Harvard in the lab of David Altshuler. Best of luck Jess beta!

  1. BulletAlex has been appointed Chief of the Division of Signal Transduction

     in the Department of Medicine, Department of Pathology and Cancer Center

     at the BIDMC. He also leads the Program in Cancer Signaling at the Cancer Center.

  1. BulletAlex presented a talk at the 2014 AACR Annual Meeting, San Diego, April 4-9.

  1. BulletThe lab attended the 2014 Cold Spring Harbor Symposium on PTEN Pathways and Targets, March 25-28. Alex and Christian gave talks, and Emilie, Evan and Rebecca presented posters.

  1. BulletWhitney Henry has been awarded an Albert J. Ryan Fellowship for 2014. Congratulations Whitney!

  1. BulletAlex gave a talk at the Novartis Institutes for Biomedical Research in Basel, Switzerland on January 22, 2014.

  1. BulletAlex presented a talk at Cancer Grand Rounds at SUNY Stonybrook on January 9 2014.


  1. BulletBanner event!! Jessica Gasser defense her PhD Thesis on

     December 18, 2013!! Congratulations Dr. Jessica beta!! Pics here!

  1. BulletPaper published! Targeting Akt3 Signaling in Triple Negative Breast

     Cancer. Y Rebecca Chin, Taku Yoshida, Andriy Marusyk,

     Andrew H. Beck, Kornelia Polyak and Alex Toker.

        Cancer Research 2013  doi: 10.1158/0008-5472.CAN-13-2175

        Featured in F1000!

  1. BulletAlex gave a talk at the Novartis Institutes for Biomedical Research

     on December 4, 2013. 

  1. BulletAlex Toker is featured in an interview as a new

    JBC Associate Editor in ASBMB Today magazine

  1. BulletPaper published! The Adherens Junction Protein Afadin is an Akt substrate that Regulates Breast Cancer Cell Migration. Sivan Elloul, Dmitriy Kedrin, Nicholas W. Knoblauch, Andrew H. Beck and Alex Toker. Molecular Cancer Research 2013, doi: 10.1158/1541-7786.MCR-13-0398.

            And we made the cover!

  1. BulletThe lab welcomes Christian Dibble who joins the Toker lab

     as a post-doctoral fellow. Welcome Christian!

  1. BulletAlex Toker gave a talk at the 2013 SAIB Symposium on Molecular

     Mechanisms in Cell Signaling and Gene Expression

      in Buenos Aires, Argentina, November 6-7, 2013.

  1. BulletKristin Brown attended the AACR-NCI-EORTC Symposium on

     Molecular Targets and Cancer Therapeutics in Boston, MA, October 19-23, and presented a poster.

  1. BulletAlex Toker gave a talk at the Workshop on Phosphorylation, Signaling

     and Disease: Targets and Targeting, in Modena, Italy, 27 September 2013.

  1. BulletRebecca Chin has been promoted to Assistant Professor of Pathology at

     Beth Israel Deaconess Medical Center, Harvard Medical School!

     Rebecca will be setting up her lab in the Department of Pathology at BIDMC.

     Congratulations Rebecca!!  

  1. BulletAura Kaunisto has left the lab and taken a position at Alligator Bioscience

     Lund, Sweden. Best of luck Aura!

  1. BulletThe lab welcomes back Abbe Clark who is joining the lab for her thesis project. Welcome Abbe!

  1. BulletAlex Toker attended the FASEB Summer Research Conference on Protein Kinases and Protein Phosphorylation in Niagara Falls, NY, July 21-26.

  1. BulletWhitney Henry has been awarded a 2013 Howard Hughes Medical Institute (HHMI) International Student Research Fellowship!! Congratulations Whitney!!

  1. BulletThe lab welcomes Rachel Guerra, BBS program, for her lab rotation!

  1. BulletToker lab summer fun day outing at Moxie Whitewater Rafting

     Adventures. Fabulous wet fun all around!! More pics here.

  1. BulletLab wedding! Jessica Gasser was married to Mike Bradshaw,

     8 June 2013. Congratulations to the newlyweds!

  1. BulletThe lab welcomes Abbe Clark, BBS program, for her lab rotation!

  1. BulletKristin received a Best Poster Award at this year’s Annual

     HMS Pathology Retreat, May 3 2013. Congrats Kristin!

  1. BulletAlex, Kristin, Emilie, Aura, Sivan and Rebecca

    attended the 2013 Annual AACR (American Association

    for Cancer Research) Meeting in Washington, DC, April 6-10.

    Kristin, Emilie, Aura, Sivan and Rebecca presented posters,

    and Kristin was awarded a 2013 Women in Cancer Research

    Scholar Award. Congratulations Kristin!!

  1. BulletEvan Lien has been awarded a 2013 NSF (National Science Foundation)

     Graduate Research Foundation Fellowship! Congratulations Evan!!


Archived News