The Toker Laboratory

2020

Alex Toker is a Professor in the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School, and Chief of the Division of Signal Transduction in Departments of Medicine, Pathology and Cancer Center. The lab has membership in the Biological and Biomedical Sciences PhD Program, the Dana-Farber/Harvard Cancer Center, and the Ludwig Center at Harvard.


Our research focuses on the cell and molecular biology of cancer. We are investigating the mechanisms by which signaling pathways impact tumor cell survival, invasion and metastasis. We are also studying metabolic alterations in tumor cells and how these lead to vulnerabilities that can be used to target tumors with specific therapies.  Our goal is to decipher the complex mechanisms by which these pathways impact cancer progression, with the ultimate goal of developing drugs that interfere with malignancy.





The Toker lab gathers for Super Bowl LIV which this year

due to an unfortunate administrative error does NOT feature

the New England Patriots. Still, there’s always next year..!


News and Views article by Alex Toker in Science magazine on new paper on double PIK3CA mutations in cancer. 

    Toker A. Double trouble for cancer gene. Science. 2019;366(6466):685–686. doi:10.1126/science.aaz4016


Paper published! What a way to start the new year and decade! Congratulations to Emily Erickson, graduate student in the BBS Program, for a co-first paper. 

    You I, Erickson EC, Donovan KA, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020;27(1):66–73.e7. doi:10.1016/j.chembiol.2019.11.014



2019


Alex gave a talk in the Department of Molecular Biology at UT Southwestern Medical Center, December 3rd


Annual Manning-Toker-Dibble labs Retreat at Oliver Lodge, Lake  Winnipesaukee, NH, September 25-27. 3 days of science, fun and games! Photos here


Alex gave a talk at the PTEN and its Pathways Symposium at BIDMC, Sept 24-25. 


Toker Lab Summer BBQ August 2019. Burgers, dogs and s’mores!


Toker Lab Summer Fun Day at the Barnstable County Fair on Cape Cod, July 27! Rides, goats, deep fried stuff, and so much more!!


Alex and Emily Erickson attended the FASEB Science Research Conference on Protein Kinases and Protein Phosphorylation in  Palm Springs, July 7-12. Alex gave a talk, and Emily presented

a short talk. Alex is the co-chair of this SRC in 2021 along with Anton Bennett, Yale U.  


Renee attended the Gordon Research Conference on Polyamines In Waterville Valley, NH. Renee was selected for a short talk, and won a travel award! Congrats Renee!


Alex gave a talk at the Center for Therapeutic Innovation International Showcase meeting at the University of Bath, UK, on June 25th. 


Alex and Hui attended and presented at a symposium at Novartis Institutes for Biomedical Research on June 21st to celebrate Lew Cantley’s 70th birthday AND the approval of the PIK3CA inhibitor Piqray!! So many old friends and colleagues to celebrate with!


Ther lab bids farewell to Richard Thornton who heads off to Princeton for his PhD studies. Best of luck Richard!


The lab welcomes new research assistant Amber Chopelas. Welcome Amber!!


The lab welcomes back new BBS graduate student Alissandra Hillis who joins the Toker lab for her PhD research. Welcome Ali!!


Sam attended and presented a poster at the CSHL Meeting on Mechanisms of Metabolic Signaling


Alex receives a new R01 award from the National Cancer Institute!


Alex is part of a DFCI/HSPH/BIDMC team that receives a grant award from the Breast Cancer Research Foundation to study the targeting of androgen receptor in breast cancer patients.


Renee receives an award from the PEO, the Philanthropic  Educational Organization, devoted to advancing women in science.  Congrats Renee!!


Adrija Navarro receives best poster prize at the annual Landry Cancer Biology Consortium Symposium. Congrats to Adrija!!


Sam Barritt and Adrija Navarro pass their pre-qualifying exams with flying colors!! Congrats!!


Lab Ski Trip at Gunstock, NH! Alpine and Nordic skiing, and some apes-ski! Photos here. 


Lab Dim Sum outing on St Patrick’s Day, of course! Yum!!


Team building and nerdy fun Lab outing at Boda Borg!


Alex receives a 2019 Exceptional Project Grant Award from the  Breast Cancer Alliance, to study precision medicine approaches to  target triple negative breast cancer!


The lab ‘celebrates’ another New England Patriots Super Bowl Victory!  That’s 6 for the home town team!! 


Alex gave a seminar in the Cancer Genetics and Genomics Department at Roswell Park Comprehensive Cancer Center, University of Buffalo, NY. 


The lab welcomes Alissandra Hillis for her second rotation in the HMS BBS Program. Welcome Ali!


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