Alex Toker is a Professor in the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School, and Chief of the Division of Signal Transduction in Departments of Medicine, Pathology and Cancer Center. The lab has membership in the Biological and Biomedical Sciences PhD Program, the Dana-Farber/Harvard Cancer Center, and the Ludwig Center at Harvard.
Our research focuses on the cell and molecular biology of cancer. We are investigating the mechanisms by which signaling pathways impact tumor cell survival, invasion and metastasis. We are also studying metabolic alterations in tumor cells and how these lead to vulnerabilities that can be used to target tumors with specific therapies. Our goal is to decipher the complex mechanisms by which these pathways impact cancer progression, with the ultimate goal of developing drugs that interfere with malignancy.
Happy New Year from the Toker Lab!
The lab bids farewell to Veronica Cocetta and Cecilia Perrone. Best of luck Veronica and Ceci!
Alex gave a talk at the 2018 San Antonio Breast Cancer Symposium, Dec 3-7, in the session on Metabolic Reprogramming in Breast Cancer
Alex gave a seminar at NYU School of Medicine, Perlmutter
Toker Lab annual Halloween Party! A lot of black
and some gold this year! Photos here!
Hui gave a talk at the first DF/HCC Preclinical Cancer Science
Symposium in the Jimmy Fund Auditorium at the DFCI! Renee
won a best poster prize!
The Red Sox win the World Series and the Toker lab celebrates!
Alex gave a talk at the 58th Annual ABR Meeting in Bologna, Italy.
The Annual Manning-Toker-Dibble Labs Retreat at Oliver Lodge,
Meredith, New Hampshire. Three days of science and fun! Photos here!
Alex gave the Keynote Lecture at the University of Torino
Annual Research Day, hosted by Prof. Emilio Hirsch.
Alex won the 2018 BBS Award for Mentoring and attended
the annual program retreat with his students.
Toker lab Summer Fun Day, thwarted by the rain..
Bowling, flatbread and drinks! Photos here.
The lab welcomes Veronica Cocetta, PhD student
from the University of Padova. Welcome Veronica!!
The lab welcomes back Adrija Navarro who joins
the Toker Lab for her PhD. Welcome back Adrija!!
Alex gave a talk at the FASEB Summer Research Conference on Cell Signaling in Cancer: From Mechanisms to Therapy, June 3-8, Steamboat Springs, CO. Emily Cohen gave a short talk, and Emily Erickson presented a poster. Photos here!
Alex gave a talk at the Dana Farber / Harvard Cancer Center Symposium on Cancer Metabolism, May 23.
The lab welcomes Georgia Stirtz for her third rotation in the BBS graduate program. Welcome Georgia!
Hui gave a talk at the annual Dana Farber/Harvard Cancer Center Breast and Gynecologic Symposium, March 16.
Paper published! Congrats to Emilie Clement! Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Emilie Clement, Hiroyuki Inuzuka, Naoe T. Nihira, Wenyi Wei, Alex Toker. Science Signaling 2018: Vol. 11, Issue 521, eaao3810 DOI: 10.1126/scisignal.aao3810
Toker Lab Annual Ski trip at Waterville Valley, NH, March 5th 2018!
Alpine skiing, Nordic skiing, drinks and only one minor injury!
See more pics here.
Renee Geck and recent Toker lab alumni Evan Lien and Kristin Brown attended and presented posters at the Keystone Symposium on Tumor Metabolism in SnowBird, Utah, January 21 2018.
The lab welcomes Adrija Navarro for her second rotation in the BBS program. Welcome Adrija!