Publications

Selected Recent Primary Research Articles

Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology 2016; 18(5): 572-8. Medline

  Mancini ML, Lien EC, Toker A. Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis. Oncotarget 2016; 7(14): 17301-13. Medline

  Brown KK, Montaser-Kouhsari L, Beck AH, Toker A. MERIT40 Is an Akt Substrate that Promotes Resolution of DNA Damage Induced by Chemotherapy. Cell Reports 2015; 11(9): 1358-66. Medline

  Kaunisto A, Henry WS, Montaser-Kouhsari L, Jaminet SC, Oh EY, Zhao L, Luo HR, Beck AH, Toker A. NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Molecular Oncology 2015; 9(6): 1140-54. Medline

  Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Molecular Cell 2014; 56(4): 595-607. Medline

  Chin YR, Yuan X, Balk SP, Toker A. PTEN-deficient tumors depend on AKT2 for maintenance and survival. Cancer Discovery 2014; 4(8): 942-55. Medline

  Chin YR, Yoshida T, Marusyk A, Beck AH, Polyak K, Toker A. Targeting Akt3 signaling in triple-negative breast cancer. Cancer Research 2014; 74(3): 964-73. Medline

  Elloul S, Kedrin D, Knoblauch NW, Beck AH, Toker A. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Molecular Cancer Research 2014; 12(3): 464-76. Medline

  Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher ON, Brown LF, Toker A, Prendergast GC, Benjamin LE. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Research 2012; In press. Medline

  Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of skp2 function. Cell. 2012; 150(1):179-93. Medline

  Christoforides, C. V., Rainero, E., Brown, K. K., Norman, J. C. and Toker, A. PKD Controls v3 Integrin Recycling and Tumor Cell Invasive Migration Through its Substrate Rabaptin-5. Developmental Cell 2012; 11;23(3):560-72. Medline

  Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz  A, Onofrio RC, Parkin M, Pho NH, Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K, Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR, Melendez-Zajgla  J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 2012; 486(7403): 405-9. Medline

  Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. mTOR Drives Its Own Activation via SCF(βTrCP)-Dependent Degradation of the mTOR Inhibitor DEPTOR. Mol Cell. 2011; 44(2): 290-303. Medline

  Yiu, G. K., Kaunisto, A., Chin, Y. R. and Toker, A. NFAT Promotes Carcinoma Invasive Migration Through Glypican-6. Biochemical Journal  2011; 440(1):157-66. Medline

  Chin YR, Toker A.  Akt2 regulates expression of the actin-bundling protein palladin.  FEBS Lett. 2010 Dec 1;584(23):4769-74. Medline

  Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W.  Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.  Mol Cell. 2010 Sep 10;39(5):797-808. Medline

  Fry JL, Toker A.  Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.  Cancer Res. 2010 Oct 15;70(20):8187-98. Medline

  Nhek, S., Ngo, M., Yang, X., Ng, M., Field, S. J., Asara, J. M., Ridgeway, N. D. and Toker, A. Regulation of OSBP Golgi Localization Through Protein Kinase D-mediated Phosphorylation Molecular Biology of the Cell 2010; 21: 2327-2337. Medline

  Chin, Y. R. and Toker, A. The actin bundling protein Palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Molecular Cell 2010; 38: 333-344. Medline

Highlighted in Faculty of 1000

  Maurer, M., Su, T., Saal, L. H., Koujak S., Hopkins B. D., Barkley C. R., Wu, J., Nandula S., Dutta, B., Xie Y., Chin Y. R., Kim, D.-I., Ferris, J. S., Gruvberger-Saal S. K., Laakso M., Wang X., Memeo L., Rojtman A., Matos T., Yu J. S., Cordon-Cardo C., Isola J., Terry M. B., Toker A., Mills G. B., Zhao J. J., Murty V. V. V. S., Hibshoosh H., and Parsons, R. 3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma. Cancer Research 2009; 69 (15): 6299-6306. Medline

Selected Recent Review Articles

  Geck RC, Toker A. Nonessential amino acid metabolism in breast cancer. Advances in Biological Regulation 2016; in press. Medline

Toker A, Rameh L. PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K? Cancer Cell 2015; 28(2): 143-5. Medline

  Brown KK, Toker A. The phosphoinositide 3-kinase pathway and therapy resistance in cancer. F1000Prime Reports 2015; 7:13. Medline

  Clark AR, Toker A. Signalling specificity in the Akt pathway in breast cancer. Biochem Soc Trans. 2014 Oct;42(5):1349-55. doi: 10.1042/BST20140160. Review. PubMed PMID: 25233414. Medline

  Toker A, Chin YR. Akt-ing up on SRPK1: oncogene or tumor suppressor? Mol Cell. 2014 May 8;54(3):329-30. doi: 10.1016/j.molcel.2014.04.020. PubMed PMID: 24813709; PubMed Central PMCID: PMC4089875. Medline

  Toker A, Marmiroli S. Signaling specificity in the Akt pathway in biology and disease. Adv Biol Regul. 2014 May;55:28-38. doi: 10.1016/j.jbior.2014.04.001. Epub 2014 Apr 19. Review. PubMed PMID: 24794538; PubMed Central PMCID: PMC4062840. Medline

  White CD, Toker A. Using phospho-motif antibodies to determine kinase substrates. Curr Protoc Mol Biol. 2013 Jan;Chapter 18:Unit 18.20.. doi: 10.1002/0471142727.mb1820s101. PubMed PMID: 23288461. Medline

  Toker A. Phosphoinositide 3-kinases-a historical perspective. Subcell Biochem. 2012;58:95-110. doi: 10.1007/978-94-007-3012-0_4. Review. PubMed PMID: 22403075. Medline

Toker A. Achieving specificity in Akt signaling in cancer. Adv Enzyme Regul. 2011 Oct 2. Medline

Chin YR, Toker A. Akt isoform-specific signaling in breast cancer: Uncovering an anti-migratory role for palladin. Cell Adh Migr. 2011 May 1;5(3). Medline

  Toker, A. TTC3 Ubiquitination Terminates Akt-ivation. Developmental Cell 2009; 17: 752-754. Medline

  Mancini, M. and Toker, A. NFAT Proteins: Emerging Roles in Cancer Progression. (2009) Nature Reviews Cancer, 9, 810-820. Medline

  Chin, Y. R. and Toker, A.  Function of Akt Signaling in Cell Motility, Invasion and the Tumor Stroma in Cancer. (2009) Cellular Signaling, 21(4):470-476. Medline

Toker, A. mTOR and Akt signaling in cancer: SGK cycles in. (2008) Molecular Cell, 31: 6-8. Medline